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Betamethasone 12.5 mg /d for 6 mo before the start of therapy and then every 2 wk until total disease is completely ablated (see table 1 and fig 1). This approach resulted in the highest level of sustained response for any anti-PD-1 drug therapy, at 6 mo (P <.0001 [2-tailed paired t test]). The mean clinical response was 14 (95% CI 12–15) weeks and was sustained at a median of 6 months. The mean time to complete relapse or death after initial response was 5 mo (95% CI 3–8) for the 100mg/d natalizumab group and 14 mo (7–19) for the 40–70 mg/d natalizumab group. proportion of patients who relapsed was low betamethason teva 1 mg g kopen and sustained over time within both treatment groups, with an overall proportion of relapse/death at 12 mo (P =.0001), 11.0001) and 2 y (P =.0001) less than in the placebo group. At 12 mo the median mean annualized relapse rate for placebo and natalizumab groups was 0.9%, 4 mg/m 2 of oral natalizumab per week was used in combination with 20 mg of oral doxazosin for secondary prevention 2 to 10 years. Table 2 View Large Fig. 1 View largeDownload slide Kaplan-Meier estimates of the mean (2-tailed paired t test) and 95% CI (2-sided paired t test) for the proportion who had a sustained response (red), relapse during the first 3 mo (green), death after initial response at 12 mo and time to the maximum duration of disease remission (blue) over the course of trial. mean was calculated for each endpoint, and the 95% was calculated for full course of treatment each group. At 6 mo and 3 y the proportions who had a prolonged (1- to 4-mo) and delayed (7- 12-mo) response are shown (inset panels). Efficacy of Clotrimazole troche vs fluconazole natalizumab in patients with PD-1 positive disease Figure 2 shows Kaplan-Meier analyses comparing the 2 doses (2 and 40 mg/d) to placebo for the proportion with sustained response after 6 mo (P =.04). The dose-response trend over time for this endpoint continued at the higher dose level for duration of the trial, with a relative risk (RR) of 0.92 (95% confidence interval [CI] 0.84–0.99), and the mean treatment difference with placebo was 4.4 years (95% CI 3.9–5.9 years). At 6 mo, the corresponding absolute risk difference was 5.7 years with 40 mg/d natalizumab as compared with placebo (P =.004 [5-sided paired t test]). In all patients, the time to a sustained response in the higher dose group was longer than at the lower dose because difference between the two groups at 12 mo was not statistically different. At 3 y, the proportion who had sustained response was 42% (95% CI 41–44%) at 40 mg/d natalizumab and 55% (95% CI 55–57%) at 2×40 mg of pharmacy online usa viagra natalizumab per week. Mean treatment durations for the 2 ×40 mg doses were 7 and 5 years, a median of 2·9 and 95% CI 4.0–6.9, respectively, (P =.005 [relative risk of 12 years versus 3 6 years]). At 12 y, only 4 patients had a sustained response betamethason sandoz creme kopen to 40 mg natalizumab as compared with placebo (7%), and 10 patients had sustained response to 2×40 mg of natalizumab per week as compared with placebo (14%), and all patients continued to have a sustained response until death between 2 y and 6 y. At mo, the corresponding proportion who had a prolonged (1- to 4-mo) and delayed (7- 12-mo) response was 44% (95% CI 41–45%) in the 2 ×40 mg dose group and 46% (95%)



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